Table 1 Subject demographics and baseline characteristics
Patient Characteristics | AboBoNT-A (N = 253) | OnaBoNT-A (N = 103) | All Patients (N = 356) |
|---|---|---|---|
Age in Years | |||
18 to 30 | 13 (5.1%) | 4 (3.9%) | 17 (4.8%) |
31 to 40 | 37 (14.6%) | 9 (8.7%) | 46 (12.9%) |
41 to 50 | 74 (29.2%) | 18 (17.5%) | 92 (25.8%) |
51 to 60 | 58 (22.9%) | 36 (35%) | 94 (26.4%) |
61 to 70 | 45 (17.8%) | 26 (25.2%) | 71 (19.9%) |
> 70 | 26 (10.3%) | 10 (9.7%) | 36 (10.1%) |
Body Weight (kg), mean (SD) | 72.7 (14.9) | 73.7 (15.3) | 73.0 (15.0) |
Sex (n,%) | |||
Female | 162 (64%) | 69 (67%) | 231 (64.9%) |
Male | 91 (36%) | 34 (33%) | 125 (35.1%) |
Previous Surgery (n,%) | |||
No | 248 (98%) | 100 (97.1%) | 348 (97.8%) |
Yes | 5 (2%) | 3 (2.9%) | 8 (2.2%) |
Prior Treatment with BoNT-A (n,%) | |||
No | 49 (19.4%) | 7 (6.8%) | 56 (15.7%) |
Yes | 204 (80.6%) | 96 (93.2%) | 300 (84.3%) |
Tremor (n,%) | |||
Absent | 142 (56.1%) | 41 (39.8%) | 183 (51.4%) |
Present | 111 (43.9%) | 62 (60.2%) | 173 (48.6%) |
Predominant Component (n,%) | |||
Not Rotation | 49 (19.4%) | 38 (36.9%) | 87 (24.4%) |
Rotation | 204 (80.6%) | 65 (63.1%) | 269 (75.6%) |
EMG at Baseline (n,%) | |||
No | 151 (59.7%) | 40 (38.8%) | 191 (53.7%) |
Yes | 102 (40.3%) | 63 (61.2%) | 165 (46.3%) |
TWSTRS Scores at Baseline | |||
Total Score, mean (SD) | 37.8 (9.4) | 33.9 (11.1) | 37.1 (10.2) |
Severity Subscale Score, mean (SD) | 20.1 (3.5) | 18.9 (3.4) | 19.8 (3.5) |
Disability Subscale Score, mean (SD) | 11.1 (5.3) | 9.2 (6.0) | 10.7 (5.6) |
Pain Subscale Score, mean (SD) | 6.6 (4.7) | 5.8 (4.9) | 6.6 (4.8) |
EQ-5D Utility Score at Baseline, mean (SD) | 0.56 (0.03) | 0.57 (0.03) | 0.57 (0.03) |
Total Injected Units of BoNT-A, mean (SD) | 598.8 (231.9) | 172.9 (66.5) | – |