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Table 2 AbobotulinumtoxinA administration by treatment cycle

From: AbobotulinumtoxinA using 2-mL dilution (500 U/2-mL) maintains durable improvement across multiple treatment cycles

 

Treatment Cycle 1

Treatment Cycle 2

Treatment Cycle 3

All Treatment Cycles

All patients, n

112

97

93

112

 Total dose, administered in Units, mean (SD)

457.7 (75.3)

507.1 (130.3)

527.4 (166.8)

1334.8 (476.9)

 Total dose <500 U, n (%)

38 (33.9%)

31 (32.0%)

30 (32.3%)

 Total dose = 500 U, n (%)

74 (66.1%)

41 (42.3%)

38 (40.9%)

 Total dose >500 U, n (%)

0

25 (25.8%)

25 (26.9%)

Toxin-naïve patients, n

35

31

30

35

 Total dose, administered in Units, mean (SD)

492.9 (34.2)

549.5 (114.6)

596.5 (192.4)

1490.9 (468.6)

 Total dose <500 U, n (%)

2 (5.7%)

5 (16.1%)

5 (16.7%)

 Total dose = 500 U, n (%)

33 (94.3%)

15 (48.4%)

15 (50.0%)

 Total dose >500 U, n (%)

0

11 (35.5%)

10 (33.3%)

Non-naïve patients, n

77

66

63

77

 Total dose, administered in Units, mean (SD)

441.7 (83.2)

487.1 (133.2)

494.5 (143.4)

1263.8 (466.5)

 Total dose <500 U, n (%)

36 (46.8%)

26 (39.4%)

25 (39.7%)

 Total dose = 500 U, n (%)

41 (53.2%)

26 (39.4%)

23 (36.5%)

 Total dose >500 U, n (%)

0

14 (21.2%)

15 (23.8%)

  1. Drug exposure for each cycle was calculated as the sum of all doses within a cycle, across all injection sites. Total cumulative drug exposure was the sum of doses across all treatment cycles. SD Standard deviation, U Unit