Atrophy of the putamen at time of clinical motor onset in Huntington’s disease: a 6-year follow-up study

Table 2 Subcortical volumes

	Controls	Premanifest HD gene carriers		p – value non-converters vs. converters^a
	Controls	Non-converters	Converters	p – value non-converters vs. converters^a
Accumbens	0.92 (0.21)	0.86 (0.15)	0.72 (0.18) ^*	0.566
Pallidum	3.39 (0.44)	3.15 (0.50)	2.78 (0.54) ^*	0.149
Amygdala	2.19 (0.36)	2.31 (0.49)	2.01 (0.51)	0.157
Putamen	9.31 (1.30)	8.32 (1.34)^*	7.24 (1.05) ^*	0.040
Caudate nucleus	6.67 (0.88)	5.65 (0.78)^*	5.15 (0.73) ^*	0.367
Thalamus	14.79 (1.32)	14.76 (1.40)	13.87 (1.51)	0.402
Hippocampus	7.75 (0.80)	7.85 (0.97)	7.15 (0.86)	0.178

Uncorrected mean (standard deviation) subcortical volumes in ml are displayed. For converters, volumes at time of conversion are measured. For non-converters and controls, mean volumes across visits were calculated. Results of a one-way analysis of covariance (ANCOVA) for group differences with age, gender and intracranial volume as covariates. Significant difference between converters and non-converters is displayed in Italic.
^aPost-hoc analyses were adjusted for multiple comparisons using a Bonferonni correction
^*Significant difference compared to controls, p < 0.05