|
Controls
|
Premanifest HD gene carriers
|
p – value
non-converters vs. convertersa
|
---|
Non-converters
|
Converters
|
---|
Accumbens
|
0.92 (0.21)
|
0.86 (0.15)
|
0.72 (0.18) *
|
0.566
|
Pallidum
|
3.39 (0.44)
|
3.15 (0.50)
|
2.78 (0.54) *
|
0.149
|
Amygdala
|
2.19 (0.36)
|
2.31 (0.49)
|
2.01 (0.51)
|
0.157
|
Putamen
|
9.31 (1.30)
|
8.32 (1.34)*
|
7.24 (1.05) *
|
0.040
|
Caudate nucleus
|
6.67 (0.88)
|
5.65 (0.78)*
|
5.15 (0.73) *
|
0.367
|
Thalamus
|
14.79 (1.32)
|
14.76 (1.40)
|
13.87 (1.51)
|
0.402
|
Hippocampus
|
7.75 (0.80)
|
7.85 (0.97)
|
7.15 (0.86)
|
0.178
|
- Uncorrected mean (standard deviation) subcortical volumes in ml are displayed. For converters, volumes at time of conversion are measured. For non-converters and controls, mean volumes across visits were calculated. Results of a one-way analysis of covariance (ANCOVA) for group differences with age, gender and intracranial volume as covariates. Significant difference between converters and non-converters is displayed in Italic.
- aPost-hoc analyses were adjusted for multiple comparisons using a Bonferonni correction
- *Significant difference compared to controls, p < 0.05