Table 4 Baseline and endpoint scores per an Intention to Treat Analysis

ESS Total

11.1 ± 4.9

9.5 ± 5.8

0.048

9.3 ± 6.2

8.1 ± 4.8

0.25

FSS Total

27.3 ± 13.1

25.4 ± 13.6

0.20

29.1 ± 12.2

29.2 ± 12.6

0.70

ISI Total

15.7 ± 3.0

11.2 ± 5.6

0.007

15.4 ± 2.9

12.2 ± 5.1

0.008

UPDRS1b Total

9.8 ± 4.0

8.1 ± 4.2

0.010

9.4 ± 2.1

8.4 ± 2.5

0.043

UPDRS1b Modified

5.4 ± 3.4

5.0 ± 3.2

0.34

5.1 ± 2.0

4.9 ± 1.7

0.58

UPDRS2 total

12.6 ± 7.9

12.5 ± 7.0

0.93

10.4 ± 7.1

10.2 ± 8.0

0.77

PDQ Total

14.4 ± 4.4

14.2 ± 4.3

0.52

15.2 ± 5.8

14.6 ± 5.6

0.32

PHQ9 Total

7.8 ± 5.1

5.8 ± 5.5

0.011

7.2 ± 4.2

5.9 ± 4.1

0.14

pirs20 Total

9.1 ± 2.4

7.2 ± 3.5

0.004

9.1 ± 2.1

7.5 ± 3.9

0.070

EQ5D Index

0.75 ± 0.15

0.72 ± 0.16

0.23

0.79 ± 0.13

0.76 ± 0.16

0.49