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Table 1 Serum and CSF Electrophoresis and GAD65 Antibody Titers

From: A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies

Sample Total Protein (g/dl) Albumin (%) Globulins (%) Anti-GAD65 Antibody Titer (IU/ml)
α - 1 α - 2 β γ
Negative Control Canine Seruma 6.9 ± 1.0 44.7 ± 3.9 11.3 ± 2.4 14.9 ± 3.1 21.6 ± 3.5 8.5 ± 1.0 8.0 ± 1.2
SDS Canine Serum Day 1 8.1 37.1 8.2 12.2 17.8 24.7 348 ± 25.1
SDS Canine Serum Day 6 7.4 41.2 8.4 11.6 19.5 19.3 77 ± 9.5
SDS Canine Serum Day 25 7.5 NA NA NA NA NA 106 ± 17.1
SDS Canine Serum Day 100 7.8 NA NA NA NA NA 46 ± 13.1
Human AntiGAD-65 Ab Positive Serum 7.2 NA NA NA NA NA 38 ± 8.5
Control CSFa 0.018 ± 2.4 39.7 ± 3.5 11.3 ± 1.5 15.8 ± 1.7 20.6 ± 3.3 7.6 ± 1.2 ND
SDS Canine CSF Day 1 0.1 NA NA NA NA NA NA
SDS Patient CSF Day 6 0.025 39.2 8.5 14.6 18.2 19.5 54 ± 8.0
  1. IDDM Insulin-dependent diabetes mellitus, A not assayed, ND not detectable; all replicates below detection threshold and not different than assay blanks
  2. aControl values represent means +/− SD obtained from samples obtained from 6 healthy female beagle dogs < 3 years of age