Fig. 2

Localization in SGMDs. The figure illustrates the anatomical localization from the spinal cord, including the spinal reflex loop with inhibitory interneurons. The propriospinal pathway is shown on the opposite side. The interneurons and alpha-motor neuron also receives supraspinal control via the descending tracts. Higher levels of control including brainstem and thalamus are also depicted. The table demonstrates the location(s) that is(are) responsible for the pathophysiology in each SGMD. The location is classified as 1) the spinal cord including spinal interneurons, spinal reflex loops and other spinal locations, and 2) supraspinal control including descending tracts (part of which is also located in the spinal cord), brainstem and others