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Fig. 1 | Journal of Clinical Movement Disorders

Fig. 1

From: The diagnostic value of saccades in movement disorder patients: a practical guide and review

Fig. 1

Pulse-step commands of saccades. X-axis represents activity of responsible neurons or muscles, and y-axis represents time. In initiation of saccades, pulse command is generated by increased firing of excitatory burst neurons, which are the paramedian pontine reticular formation (PPRF) in the pons and the rostral interstitial nucleus of the medial longitudinal fasciculus (RIMLF) in the midbriain, for the horizontal and vertical saccades, respectively. When the eyes reach the new position, step command keeps the eyes with the new level of tonic firing of the responsible neurons, which are the medial vestibular nucleus (MVN) and nucleus prepositus hypoglossi (NPH) in the medulla and the interstitial nucleus of Cajal (INC), for the horizontal and vertical saccades, respectively. Pulse height and area under the curve (or “pulse amplitude) are shown

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