From: Hydrocephalic Parkinsonism: lessons from normal pressure hydrocephalus mimics
Case | Age, gender | Disease duration at presentation | Initial clinical features | Late clinical features | Response to VPS | Pathology |
---|---|---|---|---|---|---|
1 [1] | 82, F* | 1.1 years | GD, CI, UI, postural instability | N/A | Transient improvement in GD/UI; worse at 3 years | PSP |
2 [5] | 77, M♣ | N/A | GD, CI, UI | N/A | VPS placed, outcome data not available | PSP |
3 [11] | 78, F | 2 years | GD, CI, UI, falls, generalized bradykinesia, dysarthria | Restriction of vertical eye movements, hypophonia, frontal release signs | Not placed | PSP |
4 [11] | 68, M | 4 months | GD, CI, UI, gait ignition failure, falls, hypomimia, micrographia | Restriction of vertical gaze, slow saccades, dysarthria, gait freezing | Transient improvement but progressive dementia | PSP |
5 [11] | 66, F | 2 years | GD, CI, falls, micrographia | Restriction of vertical gaze, slow saccades, dysarthria, dysphagia, gait freezing, dementia | Transient improvement in GD/CI but progressive dementia | PSP |
6 [12] | 69, M | N/A | GD, CI, UI | VSGP, akinesia, rigidity | 6-month “marked” improvement in GD, CI, and UI | PSP |
7 [1] | 66, F♦ | 3.1 years | GD, CI, UI, postural instability | “Clinical diagnosis of DLB” | Some improvement in GD at 3–6 months; no improvement at 3 years | DLB |
8 [5] | 80, M♠ | N/A | GD, CI | N/A | VPS placed, outcome data not available | DLB |
9 [7] | 87, F | 2 years | GD, CI, UI | Postural instability, falls, rare visual hallucinations | Initial marked improvement in GD/CI – No follow-up data. | DLB |