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Table 1 NPH-like presentations for pathology-confirmed PSP and DLB cases: summary of the published literature

From: Hydrocephalic Parkinsonism: lessons from normal pressure hydrocephalus mimics

Case

Age, gender

Disease duration at presentation

Initial clinical features

Late clinical features

Response to VPS

Pathology

1 [1]

82, F*

1.1 years

GD, CI, UI, postural instability

N/A

Transient improvement in GD/UI; worse at 3 years

PSP

2 [5]

77, M

N/A

GD, CI, UI

N/A

VPS placed, outcome data not available

PSP

3 [11]

78, F

2 years

GD, CI, UI, falls, generalized bradykinesia, dysarthria

Restriction of vertical eye movements, hypophonia, frontal release signs

Not placed

PSP

4 [11]

68, M

4 months

GD, CI, UI, gait ignition failure, falls, hypomimia, micrographia

Restriction of vertical gaze, slow saccades, dysarthria, gait freezing

Transient improvement but progressive dementia

PSP

5 [11]

66, F

2 years

GD, CI, falls, micrographia

Restriction of vertical gaze, slow saccades, dysarthria, dysphagia, gait freezing, dementia

Transient improvement in GD/CI but progressive dementia

PSP

6 [12]

69, M

N/A

GD, CI, UI

VSGP, akinesia, rigidity

6-month “marked” improvement in GD, CI, and UI

PSP

7 [1]

66, F

3.1 years

GD, CI, UI, postural instability

“Clinical diagnosis of DLB”

Some improvement in GD at 3–6 months; no improvement at 3 years

DLB

8 [5]

80, M

N/A

GD, CI

N/A

VPS placed, outcome data not available

DLB

9 [7]

87, F

2 years

GD, CI, UI

Postural instability, falls, rare visual hallucinations

Initial marked improvement in GD/CI – No follow-up data.

DLB

  1. GD: gait disturbance; CI: cognitive impairment; UI: urinary incontinence; VSGP: vertical supranuclear gaze palsy. *: VPS placed at 82 (no age at presentation given); ♣: Death at 77 (no age at presentation given); ♦: VPS placed at 66 (no age at presentation given); ♠: Death at 80 (no age at presentation given).