Characterization of vitamin D supplementation and clinical outcomes in a large cohort of early Parkinson’s disease

Table 4 Change in Outcomes at 3-year Visit according to mixed models^a

Outcome	Group	Estimate	P value
Change in UPDRS total	No Supplement	.	.
	MVI	0.248	0.77
	D	−1.517	0.43
	D + MVI	2.540	0.10
Change in UPDRS ADL	No Supplement	.	.
	MVI	0.117	0.70
	D	−0.555	0.43
	D + MVI	0.469	0.41
Change in UPDRS mental	No Supplement	.	.
	MVI	−0.058	0.58
	D	0.083	0.73
	D + MVI	0.083	0.67
Change in PDQ39	No Supplement	.	.
	MVI	−0.571	0.43
	D	− 0.986	0.55
	D + MVI	−0.422	0.75
Change in SDMT	No Supplement	.	.
	MVI	−0.041	0.95
	D	−0.654	0.67
	D + MVI	0.871	0.48
Change in Total daily LED	No Supplement	.	.
	MVI	−23.174	0.34
	D	−63.506	0.25
	D + MVI	−19.346	0.66

Abbreviations: UPDRS Unified Parkinson’s Disease Rating Scale, ADL activities of daily living, PDQ Parkinson’s disease questionnaire, SDMT symbol digit modalities test, LED levodopa equivalent dose
^aModel controlled for baseline age and the corresponding baseline score as fixed effects and including site as a random effect

ISSN: 2054-7072