Table 1 Case series
From: Isolated vocal tremor as a focal phenotype of essential tremor: a retrospective case review
Case | Gender | Age of onset | Duration (years) | Family history | Alcohol response | Medications | Head tremor | Kinetic arm tremor | Rest tremor | Video-stroboscopy | Visible palatal or pharyngeal muscle tremor | Response to 1 gm sodium oxybate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 56 | 4 | No | Unaware | Primidone (mild response, side effects) | No | No | No | Yes | Yes | N/A |
2 | F | 71 | 3 | No | Yes | None | Slight | Slight | No | Yes | Not commented upon | N/A |
3 | F | 64 | 2 | Vocal tremor (Mother) | Unaware | None | Slight | No | No | No | Yes | N/A |
4 | F | 70 | 10 | No | Unaware | Lorazepam (slight improvement) | Slight | No | No | No | Yes | N/A |
5 | F | 69 | 2 | No | Unaware | Atenolol (No response) | Slight | No | No | Yes | Yes | N/A |
6 | F | 87 | 1 | No | Unaware | Lorazepam (No Response) | Slight | No | No | No | Yes | N/A |
7 | F | 54 | 15 | Parkinson | Yes | None | No | Slight | No | No | Yes | Mild improvement |
8 | F | 69 | 3 | Action tremor (Mother), Vocal tremor (Sister) | Yes | Mirapex (No response); Primidone (No Response) | No | Slight | No | Yes | Not Commented Upon | Mild improvement |
9 | F | 56 | 5 | Vocal tremor (Mother, Sister) | Yes | Propranolol (No Response) | No | No | No | Yes | Yes | Mild improvement |
10 | F | 64 | 6 | No | Unaware | Propranolol (No Response) | No | No | No | Yes | Yes | Mild improvement |
11 | M | 72 | 15 | No | Yes | None | Slight | No | No | No | Yes | Mild improvement |
12 | F | 63 | 2 | Action tremor (Father) | Yes | Primidone (Unknown Response) | No | No | No | No | Yes | N/A |
13 | F | 66 | 3 | Vocal tremor (Mother) | Unaware | Primidone (Mild improvement, Yes side effects) | No | Slight | No | No | Yes | N/A |
14 | F | 45 | 20 | Action tremor (Father, Son) | Yes | Primidone (Moderate improvement) | Slight | No | Slight | No | Yes | N/A |
15 | F | 70 | 2 | No | Unaware | None | No | No | No | No | Yes | N/A |
16 | F | 81 | 3 | No | Yes | Primidone (Moderate improvement) | No | No | No | No | Yes | N/A |
17 | M | 56 | 6 | Tremor (Father, Paternal Aunt/Uncle/Grandmother | Yes | Propranolol (Mild improvement) | No | No | No | Yes | Yes | Mild improvement |
18 | F | 65 | 9 | No | Yes | Propranolol, Primidone (Mild improvement) | Slight | Slight | No | Yes | Yes | Mild improvement |
19 | F | 45 | 2 | Action tremor (Father), Vocal tremor (Paternal Aunt) | Yes | Propranolol (Moderate improvement) | No | No | No | Yes | Yes | N/A |